Vaccination against the nematode Haemonchus contortus with a thiol-binding fraction from the excretory/secretory products (ES)
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منابع مشابه
Vaccination against the nematode Haemonchus contortus with a thiol-binding fraction from the excretory/secretory products (ES).
Fractionated excretory/secretory products (ES) of adult Haemonchus contortus were evaluated as protective antigens. The proteins were successively eluted from a Thiol Sepharose column using 25 mM cysteine followed by 25 mM Dl-dithiothreitol (DTT). Sheep were vaccinated three times and challenged with 5000 third stage infective larvae (L3) of H. contortus. Highest level of protection was found i...
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Haemonchus contortus, a highly pathogenic and economically important parasitic nematode of sheep, is particularly adept at developing resistance to the anthelmintic drugs used in its treatment and control. The basis of anthelmintic resistance is poorly understood for many commonly used drugs with most research being focused on mechanisms involving drug targets or drug efflux. Altered or increas...
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The phase II detoxification system glutathione transferase (GST) is associated with the establishment of parasitic nematode infections within the gastrointestinal environment of the mammalian host. We report the functional analysis of a GST from an important worldwide parasitic nematode of small ruminants, Haemonchus contortus. This GST shows limited activity with a range of classical GST subst...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2004
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2003.08.025